Name | 5-Chlorosalicylic acid |
Synonyms | 5 CSA JACS-321-14-2 5-chloro-salicylicaci 5-Chlorosalicylic acid CHLOROSALICYLIC(5-) ACID 5-chloro-2-hydroxybenzoate 5-chloro-2-hydroxy-benzoicaci 2-Hydroxy-5-chlorobenzoic acid 5-Chloro-2-hydroxybenzoic acid 2-Hydroxy-5-Chloro Benzoic Acid 5-Chloro-2-hydroxybenzoic acid for synthesis |
CAS | 321-14-2 |
EINECS | 206-283-9 |
InChI | InChI=1/C7H5ClO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9H,(H,10,11)/p-1 |
Molecular Formula | C7H5ClO3 |
Molar Mass | 172.57 |
Density | 1.3766 (rough estimate) |
Melting Point | 171-172°C(lit.) |
Boling Point | 244.67°C (rough estimate) |
Flash Point | 147.6°C |
Water Solubility | 1 g/L (20 ºC) |
Solubility | 1g/l |
Vapor Presure | 0.000132mmHg at 25°C |
Appearance | powder to crystal |
Color | White to Almost white |
BRN | 2046665 |
pKa | pK1:2.63 (25°C) |
PH | 2.5 (H2O, 20℃)(aqueous suspension) |
Storage Condition | Inert atmosphere,Room Temperature |
Refractive Index | 1.4580 (estimate) |
MDL | MFCD00002457 |
Physical and Chemical Properties | White crystalline powder. Melting Point 73-174 °c (172 °c, 174-176 °c). Soluble in hot water, insoluble in cold water, soluble in ethanol, ether, benzene, chloroform and acetic acid. With the role of ferric chloride was red-purple. |
Use | Used as pesticide, medicine, dye intermediates |
Hazard Symbols | Xn - Harmful |
Risk Codes | R22 - Harmful if swallowed R36/38 - Irritating to eyes and skin. R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection |
UN IDs | UN 2811 6.1/PG 3 |
WGK Germany | 3 |
RTECS | VO2080000 |
TSCA | Yes |
HS Code | 29182990 |
Hazard Class | 6.1 |
Packing Group | III |
Toxicity | LD50 oral in rat: 250mg/kg |
Raw Materials | Salicylic acid Chlorine |
NIST chemical information | Information provided by: webbook.nist.gov (external link) |
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
uses | intermediates for dyes and medicines. Used as an intermediate for pesticides, medicines, and dyes |
production method | add chlorobenzene to enamel pan and steam to remove water to below 0.03%, add salicylic acid, and uniformly pass chlorine to a predetermined amount at 110±2 ℃. Sampling and observing the precipitates cooled to 30 ℃, filtering, measuring the melting point, and taking 167-175 ℃ as the qualified, that is, the chlorobenzene solution of 5-chlorosalicylic acid is obtained. If the chlorination reaction is carried out under the irradiation of fluorescent lamp, the chlorine can be reached to the theoretical amount at 55-80 ℃. After the sampling test is qualified, the remaining chlorine is removed, cooled, filtered, washed with chlorobenzene, and dried to obtain the finished product. |